Wound Care

Phenytoin

Promotes granulation (tissue proliferation) in a healing wound
Inhibits formation of collagenase, thereby, increasing collagen synthesis
Decreases exudates, Alleviates pain, Exerts an antimicrobial effect, Counteracts inflammation
Wounds healed 50 – 60% faster than non-treated wounds
Proven effective in treatment of decubitus ulcers, traumatic wounds, diabetic and burn ulcers
Used topically as solution, gel, cream or provider
Concentrations of 1% - 10% applied twice daily
Phenytoin 10 gram powder insufflator

Inhibition of calcium influx into smooth muscles decreases vascular tone, thereby, increasing blood flow and vascularization of treated area
Used topically at 5 – 20% concentrations, may be added to any formula

Synthetic prostaglandin used primarily to protect gastric mucosa by replacing endogenous prostaglandins depleted by medications such as NSAIDs. Drug’s mechanism of action aids in the acceleration of wound healing
Used topically at 0.0024% concentrations

Phosphodiesterase inhibitor used orally to reduce blood viscosity and improve circulation Enhances vascular permeability resulting in increased blood flow and oxygen delivery to wound site Improves functions of red and white blood cells and platelets
Used topically at concentrations of 5% (for adjunct therapy) to 15% (to enhance circulation)

Gentamicin - most active against aerobic gram-negative rods, but it is also used in combination with other antibiotics to treat Staphylococcus aureus and certain species of streptococcus
Clindamycin – anti-anaerobic activity, either bacteriostatic or bactericidal, depending on its concentration at the site of action and on the specific susceptibility of the organism being treated
Polymyxin B – spectrum of activity is limited to gram-negative bacteria, bactericidal against most gram-negative bacilli; however, some Proteus and Serratia species may be resistant. Polymyxin B has no in vitro activity against gram-positive organisms or fungi
G.C.P. Solution
G.C.P. Gel with Nifedipine or Phenytoin

Aminoglycoside antibiotic
Organisms susceptible to neomycin include Escherichia coli, Klebsiella, and other Enterobacteriaceae
Like other aminoglycosides, neomycin is ineffective against anaerobic bacteria

Antibacterial and antiprotozoal agent with effective coverage against many anaerobic organisms Used topically, also provides control of wound odor

The anti-inflammatory actions of corticosteroids are thought to control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of the precursor molecule arachidonic acid
Applied to surrounding wound area to control inflammation, not applied directly to wound

Used topically, has been demonstrated to inhibit pro-inflammatory enzyme cyclo-oxygenase 2 (COX-2), which in turn reduces scar formation and/or thickness

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